|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
contains FAD
|
|
gptkbp:alternativeName
|
gptkb:MAO-B
gptkb:amine_oxidase_(flavin-containing)_B
gptkb:monoamine_oxidase_type_B
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
|
|
gptkbp:catalyzes
|
oxidative deamination of amines
|
|
gptkbp:cofactor
|
gptkb:FAD
|
|
gptkbp:EC_number
|
1.4.3.4
|
|
gptkbp:encodedBy
|
gptkb:MAOB_gene
|
|
gptkbp:expressedIn
|
neurons
astrocytes
|
|
gptkbp:foundIn
|
brain
liver
platelets
outer mitochondrial membrane
|
|
gptkbp:function
|
regulates neurotransmitter levels
degrades biogenic amines
|
|
gptkbp:gene
|
gptkb:MAOB
|
|
gptkbp:GO_term
|
gptkb:GO:0008131
|
|
gptkbp:HGNC_ID
|
6833
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
monoamine oxidase B
|
|
gptkbp:inhibitedBy
|
gptkb:rasagiline
gptkb:selegiline
gptkb:safinamide
|
|
gptkbp:inhibitor_clinical_use
|
treatment of depression
treatment of Alzheimer's disease
treatment of Parkinson's disease
|
|
gptkbp:involves
|
dopamine metabolism
neurotransmitter catabolism
|
|
gptkbp:locatedOnChromosome
|
Xp11.3
|
|
gptkbp:molecularWeight
|
58 kDa
|
|
gptkbp:mutationAssociatedWith
|
may affect behavior
may affect neurodegeneration
|
|
gptkbp:OMIM
|
309860
|
|
gptkbp:orthologInMouse
|
Maob
|
|
gptkbp:PDB
|
gptkb:1GOS
|
|
gptkbp:relatedTo
|
gptkb:monoamine_oxidase_A
|
|
gptkbp:structure
|
dimer
|
|
gptkbp:substrate
|
gptkb:benzylamine
dopamine
phenylethylamine
|
|
gptkbp:type
|
reversible
irreversible
|
|
gptkbp:UniProtID
|
gptkb:P27338
|
|
gptkbp:bfsParent
|
gptkb:monoamine_oxidase_inhibitors
|
|
gptkbp:bfsLayer
|
6
|