matrix metallopeptidase 9

URI: https://gptkb.org/entity/matrix_metallopeptidase_9

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	proteolytic cleavage
gptkbp:alternativeName	gptkb:92_kDa_type_IV_collagenase gptkb:gelatinase_B collagenase type IV
gptkbp:associatedWith	gptkb:cardiovascular_disease multiple sclerosis arthritis chronic obstructive pulmonary disease cancer metastasis
gptkbp:cofactor	zinc calcium
gptkbp:discoveredBy	1989
gptkbp:EC_number	3.4.24.35
gptkbp:Entrez_Gene_ID	GC20M031384
gptkbp:expressedIn	macrophages endothelial cells fibroblasts tumor cells neutrophils
gptkbp:function	involved in angiogenesis degrades extracellular matrix proteins involved in tissue remodeling involved in leukocyte migration
gptkbp:gene	gptkb:MMP9
gptkbp:HGNC_ID	gptkb:HGNC:7156
https://www.w3.org/2000/01/rdf-schema#label	matrix metallopeptidase 9
gptkbp:inhibitedBy	gptkb:TIMP1 gptkb:TIMP2 gptkb:TIMP3 gptkb:TIMP4
gptkbp:locatedIn	chromosome 20q13.12
gptkbp:member	gptkb:matrix_metalloproteinase_family
gptkbp:molecularWeight	92 kDa
gptkbp:OMIM	120361
gptkbp:PDB	1L6J 4H3X 1GKC 5I12
gptkbp:substrate	gptkb:fibronectin gptkb:elastin gptkb:collagen_type_IV gptkb:laminin gelatin
gptkbp:UniProtID	P14780
gptkbp:bfsParent	gptkb:MMP9
gptkbp:bfsLayer	7