Statements (42)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activatedBy |
proteolytic cleavage
|
| gptkbp:alsoKnownAs |
gptkb:MMP-9
matrix metalloproteinase-9 |
| gptkbp:cofactor |
zinc
calcium |
| gptkbp:EC_number |
3.4.24.35
|
| gptkbp:encodedBy |
MMP9 gene
|
| gptkbp:Entrez_Gene_ID |
4318
|
| gptkbp:expressedIn |
macrophages
endothelial cells epithelial cells neutrophils |
| gptkbp:family |
gptkb:matrix_metalloproteinases
|
| gptkbp:foundIn |
humans
other mammals |
| gptkbp:function |
involved in inflammation
involved in tissue remodeling involved in cancer metastasis degrades gelatin degrades type IV and V collagen |
| gptkbp:GO_term |
GO:0004222
|
| https://www.w3.org/2000/01/rdf-schema#label |
gelatinase B
|
| gptkbp:inhibitedBy |
tissue inhibitors of metalloproteinases
|
| gptkbp:locatedOnChromosome |
20q11.2-q13.1 (human)
|
| gptkbp:molecularWeight |
92 kDa
|
| gptkbp:OMIM |
120361
|
| gptkbp:PDB |
1GKC
|
| gptkbp:role |
gptkb:cancer
gptkb:cardiovascular_disease multiple sclerosis arthritis chronic obstructive pulmonary disease |
| gptkbp:structure |
contains fibronectin type II-like repeats
|
| gptkbp:substrate |
gptkb:elastin
gptkb:aggrecan gptkb:collagen_type_IV gelatin collagen type V |
| gptkbp:UniProtID |
P14780
|
| gptkbp:bfsParent |
gptkb:MMP9
|
| gptkbp:bfsLayer |
7
|