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gptkbp:instanceOf
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gptkb:enzyme
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gptkbp:abbreviation
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gptkb:MMP
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gptkbp:activatedBy
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proteolytic cleavage
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gptkbp:associatedWith
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gptkb:cardiovascular_disease
chronic obstructive pulmonary disease
fibrosis
tumor invasion
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gptkbp:cofactor
|
zinc
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gptkbp:discoveredIn
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1960s
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gptkbp:EC_number
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3.4.24.-
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gptkbp:example
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gptkb:MMP-1
gptkb:MMP-2
gptkb:MMP-3
gptkb:MMP-9
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gptkbp:family
|
zinc-dependent endopeptidases
|
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gptkbp:foundIn
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animals
humans
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gptkbp:function
|
degradation of extracellular matrix
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|
https://www.w3.org/2000/01/rdf-schema#label
|
matrix metalloproteinase
|
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gptkbp:inhibitedBy
|
doxycycline
tissue inhibitors of metalloproteinases
batimastat
marimastat
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gptkbp:locatedOnChromosome
|
various chromosomes
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gptkbp:proteinFamily
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gptkb:MMP_gene_family
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gptkbp:regulates
|
cytokines
growth factors
hormones
|
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gptkbp:role
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wound healing
arthritis
angiogenesis
inflammation
cancer metastasis
tissue remodeling
|
|
gptkbp:structure
|
catalytic domain
hemopexin-like domain
pro-domain
|
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gptkbp:studiedIn
|
gptkb:medicine
biochemistry
molecular biology
|
|
gptkbp:substrate
|
gptkb:fibronectin
gptkb:elastin
collagen
gelatin
|
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gptkbp:target
|
MMP inhibitors
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gptkbp:bfsParent
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gptkb:MMP13
gptkb:metalloprotease
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gptkbp:bfsLayer
|
7
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