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gptkbp:instanceOf
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gptkb:enzyme
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gptkbp:abbreviation
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gptkb:MMP
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gptkbp:activatedBy
|
proteolytic cleavage
|
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gptkbp:associatedWith
|
gptkb:cardiovascular_disease
chronic obstructive pulmonary disease
fibrosis
tumor invasion
|
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gptkbp:cofactor
|
zinc
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|
gptkbp:discoveredIn
|
1960s
|
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gptkbp:EC_number
|
3.4.24.-
|
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gptkbp:example
|
gptkb:MMP-1
gptkb:MMP-2
gptkb:MMP-3
gptkb:MMP-9
|
|
gptkbp:family
|
zinc-dependent endopeptidases
|
|
gptkbp:foundIn
|
animals
humans
|
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gptkbp:function
|
degradation of extracellular matrix
|
|
gptkbp:inhibitedBy
|
doxycycline
tissue inhibitors of metalloproteinases
batimastat
marimastat
|
|
gptkbp:locatedOnChromosome
|
various chromosomes
|
|
gptkbp:proteinFamily
|
gptkb:MMP_gene_family
|
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gptkbp:regulates
|
cytokines
growth factors
hormones
|
|
gptkbp:role
|
wound healing
arthritis
angiogenesis
inflammation
cancer metastasis
tissue remodeling
|
|
gptkbp:structure
|
catalytic domain
hemopexin-like domain
pro-domain
|
|
gptkbp:studiedIn
|
gptkb:medicine
biochemistry
molecular biology
|
|
gptkbp:substrate
|
gptkb:fibronectin
gptkb:elastin
gptkb:collagen
gelatin
|
|
gptkbp:target
|
MMP inhibitors
|
|
gptkbp:bfsParent
|
gptkb:MMP13
|
|
gptkbp:bfsLayer
|
7
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|
https://www.w3.org/2000/01/rdf-schema#label
|
matrix metalloproteinase
|