|
gptkbp:instanceOf
|
gptkb:protein
collagen
|
|
gptkbp:alternativeName
|
gptkb:type_I_collagen
|
|
gptkbp:associatedWith
|
gptkb:systemic_sclerosis
Ehlers-Danlos syndrome
osteogenesis imperfecta
|
|
gptkbp:biosynthesized_from
|
fibroblasts
osteoblasts
|
|
gptkbp:composedOf
|
one alpha-2 chain
two alpha-1 chains
|
|
gptkbp:crosslinkedBy
|
lysyl oxidase
|
|
gptkbp:degradedBy
|
collagenase
|
|
gptkbp:encodedBy
|
gptkb:COL1A1
gptkb:COL1A2
|
|
gptkbp:fibrilForming
|
true
|
|
gptkbp:firstDescribed
|
1930s
|
|
gptkbp:foundIn
|
gptkb:bone
gptkb:skin
gptkb:artery
cornea
tendon
dentin
fibrocartilage
ligament
|
|
gptkbp:function
|
structural support
provides tensile strength
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
collagen type I
|
|
gptkbp:majorComponentOf
|
extracellular matrix
scar tissue
|
|
gptkbp:molecularWeight
|
~300 kDa
|
|
gptkbp:mostAbundantCollagen
|
human body
|
|
gptkbp:postTranslationalModification
|
hydroxylation of proline and lysine
|
|
gptkbp:solubility
|
insoluble in water
|
|
gptkbp:structure
|
triple helix
|
|
gptkbp:usedIn
|
biomedical research
tissue engineering
cosmetic products
|
|
gptkbp:bfsParent
|
gptkb:DDR1
gptkb:COCA1
gptkb:MMP1
gptkb:MMP13
|
|
gptkbp:bfsLayer
|
7
|