mammalian target of rapamycin (mTOR)

URI: https://gptkb.org/entity/mammalian_target_of_rapamycin_(mTOR)
GPTKB entity
Statements (40)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy gptkb:insulin
growth factors
amino acids
energy status
gptkbp:alsoKnownAs gptkb:mechanistic_target_of_rapamycin
gptkb:FRAP
RAFT1
gptkbp:discoveredBy gptkb:David_Sabatini
gptkbp:discoveredIn 1994
gptkbp:encodedBy gptkb:MTOR_gene
gptkbp:formsComplexWith gptkb:mTORC1
gptkb:mTORC2
gptkbp:function regulation of cell proliferation
regulation of cell survival
regulation of autophagy
regulation of cell growth
regulation of cell motility
regulation of protein synthesis
https://www.w3.org/2000/01/rdf-schema#label mammalian target of rapamycin (mTOR)
gptkbp:inhibitedBy gptkb:everolimus
gptkb:rapamycin
gptkb:sirolimus
gptkb:temsirolimus
gptkbp:involvedIn gptkb:cancer
gptkb:diabetes
aging
neurodegenerative diseases
gptkbp:locatedIn gptkb:nucleus
gptkb:cytoplasm
gptkbp:locatedOnChromosome gptkb:chromosome_1p36.2
gptkbp:memberOf PI3K-related kinase family
gptkbp:phosphorylates gptkb:4EBP1
gptkb:S6K1
gptkb:ULK1
gptkb:AKT
gptkbp:species gptkb:Homo_sapiens
gptkbp:UniProtID gptkb:P42345
gptkbp:bfsParent gptkb:PI3K/AKT_signaling_pathway
gptkbp:bfsLayer 6