|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:category
|
gptkb:anticoagulant
acute-phase protein
|
|
gptkbp:cleavage
|
gptkb:thrombin
|
|
gptkbp:coagulationFactorNumber
|
gptkb:Factor_I
|
|
gptkbp:component
|
extracellular matrix
|
|
gptkbp:convertedTo
|
gptkb:fibrin
|
|
gptkbp:decreasedIn
|
gptkb:liver_disease
fibrinolysis
disseminated intravascular coagulation
|
|
gptkbp:deficiencyCauses
|
afibrinogenemia
dysfibrinogenemia
hypofibrinogenemia
|
|
gptkbp:discoveredBy
|
gptkb:William_H._Howell
|
|
gptkbp:discoveredIn
|
1901
|
|
gptkbp:elevatedIn
|
gptkb:cancer
pregnancy
inflammation
|
|
gptkbp:encodedBy
|
gptkb:FGA_gene
gptkb:FGB_gene
gptkb:FGG_gene
|
|
gptkbp:foundIn
|
blood plasma
|
|
gptkbp:function
|
blood clotting
|
|
gptkbp:halfLife
|
3-5 days
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
fibrinogen
|
|
gptkbp:measures
|
gptkb:Clauss_assay
fibrinogen activity test
|
|
gptkbp:molecularWeight
|
340 kDa
|
|
gptkbp:normalPlasmaConcentration
|
2-4 g/L
|
|
gptkbp:OMIM
|
134820
134830
134850
|
|
gptkbp:PDB
|
1FZA
1FZC
3GHG
|
|
gptkbp:role
|
wound healing
angiogenesis
inflammation
cell adhesion
tissue repair
host defense
|
|
gptkbp:structure
|
hexamer
|
|
gptkbp:subunit
|
alpha chain
beta chain
gamma chain
|
|
gptkbp:synthesisType
|
liver
|
|
gptkbp:UniProtID
|
gptkb:P02671
gptkb:P02675
P02679
|
|
gptkbp:bfsParent
|
gptkb:CD61
gptkb:Thrombin
gptkb:CR3_domain
gptkb:thrombin
gptkb:Glycoprotein_IIb/IIIa
|
|
gptkbp:bfsLayer
|
6
|