|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:BSF2
gptkb:IFNB2
gptkb:interleukin_6
gptkb:HGF
|
|
gptkbp:associatedWith
|
gptkb:Castleman_disease
rheumatoid arthritis
COVID-19 severity
systemic juvenile idiopathic arthritis
|
|
gptkbp:discoveredBy
|
gptkb:Tadamitsu_Kishimoto
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodes
|
gptkb:interleukin-6
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000136244
3569
|
|
gptkbp:expressedIn
|
endothelial cells
fibroblasts
immune cells
|
|
gptkbp:function
|
inflammatory response
immune response regulation
cytokine activity
|
|
gptkbp:HGNC_ID
|
6018
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL6 gene
|
|
gptkbp:length
|
212 amino acids
|
|
gptkbp:locatedOnChromosome
|
7p15.3
|
|
gptkbp:mutationAssociatedWith
|
autoimmune disease susceptibility
altered immune response
increased inflammation
|
|
gptkbp:OMIM
|
147620
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Il6
|
|
gptkbp:pathway
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
|
|
gptkbp:product
|
gptkb:IL-6
|
|
gptkbp:protein_structure
|
four-helix bundle
|
|
gptkbp:proteinFamily
|
gptkb:interleukin-6_family
|
|
gptkbp:recipient
|
gptkb:IL-6R
|
|
gptkbp:regulates
|
fever
inflammation
hematopoiesis
B cell maturation
acute phase response
|
|
gptkbp:targetOfDrug
|
gptkb:tocilizumab
gptkb:sarilumab
gptkb:siltuximab
|
|
gptkbp:transcriptionFactorBinding
|
gptkb:CREB
gptkb:NF-κB
gptkb:AP-1
C/EBPβ
|
|
gptkbp:UniProtID
|
gptkb:P05231
|
|
gptkbp:bfsParent
|
gptkb:interleukin-6
|
|
gptkbp:bfsLayer
|
6
|