Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:CD126
Interleukin-6 receptor |
| gptkbp:associatedWith |
gptkb:Castleman_disease
autoimmune diseases rheumatoid arthritis COVID-19 cytokine storm |
| gptkbp:binds |
gptkb:Interleukin-6
|
| gptkbp:composedOf |
gptkb:IL6R_alpha_chain
gp130 (IL6ST) |
| gptkbp:discoveredBy |
gptkb:Tadamitsu_Kishimoto
|
| gptkbp:discoveredIn |
1988
|
| gptkbp:encodedBy |
gptkb:IL6R_gene
|
| gptkbp:expressedIn |
gptkb:leukocytes
gptkb:hepatocytes macrophages neutrophils |
| gptkbp:function |
mediates IL-6 signaling
|
| https://www.w3.org/2000/01/rdf-schema#label |
IL-6 receptor
|
| gptkbp:involvedIn |
inflammation
immune response |
| gptkbp:isSolubleIn |
soluble IL-6 receptor (sIL-6R)
|
| gptkbp:locatedOn |
gptkb:cell_membrane
|
| gptkbp:locatedOnChromosome |
1q21
|
| gptkbp:OMIM |
147880
|
| gptkbp:structure |
extracellular domain
transmembrane protein cytoplasmic domain |
| gptkbp:target |
gptkb:tocilizumab
gptkb:sarilumab |
| gptkbp:UniProtID |
P08887
|
| gptkbp:bfsParent |
gptkb:interleukin-6
|
| gptkbp:bfsLayer |
6
|