hypoxia-inducible factor (HIF)

URI: https://gptkb.org/entity/hypoxia-inducible_factor_(HIF)
GPTKB entity
Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:activatedBy low oxygen levels
gptkbp:associatedWith gptkb:cancer
gptkb:anemia
ischemia
gptkbp:binds gptkb:hypoxia_response_elements_(HREs)
gptkbp:component gptkb:HIF-1α
gptkb:HIF-1β
gptkb:HIF-2α
gptkb:HIF-3α
gptkbp:degradedBy gptkb:proteasome
gptkb:prolyl_hydroxylase
gptkb:von_Hippel-Lindau_protein
gptkbp:discoveredBy gptkb:Gregg_L._Semenza
gptkbp:function regulation of cellular response to hypoxia
gptkbp:gene gptkb:EPAS1
gptkb:HIF1A
gptkb:HIF3A
gptkbp:heterodimer HIF-1α and HIF-1β
https://www.w3.org/2000/01/rdf-schema#label hypoxia-inducible factor (HIF)
gptkbp:locale cell nucleus
gptkbp:NobelPrizeYear gptkb:2019_Nobel_Prize_in_Physiology_or_Medicine
gptkbp:regulates cell proliferation
angiogenesis
glycolysis
VEGF expression
erythropoietin gene expression
glucose transporter expression
hepcidin expression
ADM expression
ALDOA expression
BNIP3 expression
CA9 expression
CXCR4 expression
ENO1 expression
HK2 expression
LDHA expression
NOS2 expression
PDK1 expression
PGK1 expression
SLC2A1 expression
adrenomedullin expression
endothelin-1 expression
insulin-like growth factor 2 expression
lactate dehydrogenase expression
matrix metalloproteinase expression
pyruvate dehydrogenase kinase expression
transferrin expression
gptkbp:bfsParent gptkb:VHL_gene
gptkb:hypoxia_response_elements_(HREs)
gptkb:von_Hippel-Lindau_protein_(VHL)
gptkb:pVHL_protein
gptkbp:bfsLayer 7