prolyl hydroxylase

GPTKB entity

Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName procollagen-proline dioxygenase
proline hydroxylase
gptkbp:associatedWith gptkb:scurvy
fibrosis
hypoxia-inducible factor regulation
gptkbp:biologicalProcess oxidoreductase activity
collagen metabolic process
gptkbp:catalyzes hydroxylation of proline residues
gptkbp:cellularComponent gptkb:endoplasmic_reticulum
gptkbp:cofactor iron
ascorbate
gptkbp:discoveredBy 1967
gptkbp:EC_number 1.14.11.2
gptkbp:encodedBy gptkb:P4HA1
gptkb:P4HA2
gptkb:P4HA3
gptkbp:foundIn animals
humans
plants
https://www.w3.org/2000/01/rdf-schema#label prolyl hydroxylase
gptkbp:importantFor collagen biosynthesis
gptkbp:inhibitedBy gptkb:dimethyloxalylglycine
cobalt chloride
gptkbp:product 4-hydroxyproline
gptkbp:proteinFamily gptkb:P4HA
gptkbp:requires gptkb:2-oxoglutarate
molecular oxygen
gptkbp:substrate proline
gptkbp:subunit alpha subunit
beta subunit
gptkbp:bfsParent gptkb:HIF
gptkbp:bfsLayer 7