Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
procollagen-proline dioxygenase
proline hydroxylase |
| gptkbp:associatedWith |
gptkb:scurvy
fibrosis hypoxia-inducible factor regulation |
| gptkbp:biologicalProcess |
oxidoreductase activity
collagen metabolic process |
| gptkbp:catalyzes |
hydroxylation of proline residues
|
| gptkbp:cellularComponent |
gptkb:endoplasmic_reticulum
|
| gptkbp:cofactor |
iron
ascorbate |
| gptkbp:discoveredBy |
1967
|
| gptkbp:EC_number |
1.14.11.2
|
| gptkbp:encodedBy |
gptkb:P4HA1
gptkb:P4HA2 gptkb:P4HA3 |
| gptkbp:foundIn |
animals
humans plants |
| gptkbp:importantFor |
collagen biosynthesis
|
| gptkbp:inhibitedBy |
gptkb:dimethyloxalylglycine
cobalt chloride |
| gptkbp:product |
4-hydroxyproline
|
| gptkbp:proteinFamily |
gptkb:P4HA
|
| gptkbp:requires |
gptkb:2-oxoglutarate
molecular oxygen |
| gptkbp:substrate |
proline
|
| gptkbp:subunit |
alpha subunit
beta subunit |
| gptkbp:bfsParent |
gptkb:HIF
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
prolyl hydroxylase
|