von Hippel-Lindau protein (VHL)
GPTKB entity
Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:VHL_tumor_suppressor
gptkb:pVHL |
| gptkbp:encodedBy |
gptkb:VHL_gene
|
| gptkbp:formsComplexWith |
gptkb:RBX1
gptkb:cullin_2 elongin B elongin C |
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
gptkb:tumor_suppressor
E3 ubiquitin ligase complex component |
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:mutationAssociatedWith |
gptkb:hemangioblastoma
gptkb:pheochromocytoma gptkb:von_Hippel-Lindau_disease clear cell renal cell carcinoma |
| gptkbp:PDB |
gptkb:1LM8
|
| gptkbp:regulates |
gptkb:hypoxia-inducible_factor_(HIF)
ubiquitination of HIF-1α |
| gptkbp:UniProtID |
P40337
|
| gptkbp:bfsParent |
gptkb:hypoxia-inducible_factor_1_(HIF-1)
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
von Hippel-Lindau protein (VHL)
|