|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:hypoxia
|
|
gptkbp:alsoKnownAs
|
gptkb:EPAS1
Endothelial PAS domain-containing protein 1
|
|
gptkbp:degradedBy
|
gptkb:proteasome
gptkb:VHL_protein
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:domain
|
transactivation domain
PAS domain
bHLH domain
|
|
gptkbp:encodedBy
|
EPAS1 gene
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
heart
liver
endothelial cells
|
|
gptkbp:formsComplexWith
|
gptkb:ARNT
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
transcription factor
DNA binding
transcriptional activator activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HIF-2α
|
|
gptkbp:involves
|
gptkb:cancer
pulmonary hypertension
polycythemia
|
|
gptkbp:locatedOnChromosome
|
2p21
|
|
gptkbp:memberOf
|
hypoxia-inducible factor family
|
|
gptkbp:molecularWeight
|
~87 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:pheochromocytoma
paraganglioma
familial erythrocytosis
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
3H7W
|
|
gptkbp:regulates
|
cell proliferation
angiogenesis
glucose metabolism
VEGF expression
response to hypoxia
genes involved in iron metabolism
genes involved in cell survival
erythropoietin expression
cellular adaptation to low oxygen
genes involved in energy metabolism
|
|
gptkbp:target
|
PT2385
belzutifan
|
|
gptkbp:UniProtID
|
Q99814
|
|
gptkbp:bfsParent
|
gptkb:HIF_family
gptkb:hypoxia-inducible_factors_(HIFs)
|
|
gptkbp:bfsLayer
|
7
|