|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:hypoxia
|
|
gptkbp:alias
|
gptkb:BHLHE78
gptkb:MOP1
gptkb:PASD8
gptkb:bHLHe78
|
|
gptkbp:associatedWith
|
gptkb:cancer
chronic kidney disease
pulmonary hypertension
ischemia
|
|
gptkbp:degradedBy
|
gptkb:proteasome
gptkb:VHL_protein
|
|
gptkbp:discoveredBy
|
gptkb:Gregg_L._Semenza
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodes
|
gptkb:HIF-1α_protein
|
|
gptkbp:Entrez_Gene_ID
|
3091
ENSG00000100644
|
|
gptkbp:expressedIn
|
most tissues
|
|
gptkbp:formsComplexWith
|
gptkb:ARNT
|
|
gptkbp:fullName
|
gptkb:hypoxia_inducible_factor_1_subunit_alpha
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
4910
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HIF1A
|
|
gptkbp:length
|
826 amino acids
|
|
gptkbp:locatedOnChromosome
|
14q23.2
|
|
gptkbp:molecularWeight
|
93 kDa
|
|
gptkbp:OMIM
|
603348
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hif1a
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
hydroxylation
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
angiogenesis
glycolysis
erythropoiesis
response to hypoxia
binds hypoxia response elements (HREs)
|
|
gptkbp:targetGene
|
gptkb:VEGFA
gptkb:LDHA
gptkb:EPO
gptkb:BNIP3
gptkb:GLUT1
gptkb:PGK1
gptkb:SLC2A1
CA9
|
|
gptkbp:UniProtID
|
Q16665
|
|
gptkbp:bfsParent
|
gptkb:VEGFA_gene
gptkb:hypoxia-inducible_factor_1_(HIF-1)
|
|
gptkbp:bfsLayer
|
6
|