|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:IPAS
gptkb:HIF-3α
bHLHe17
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:type_2_diabetes
obesity
pre-eclampsia
hypoxia response
|
|
gptkbp:encodes
|
gptkb:HIF-3α
|
|
gptkbp:Entrez_Gene_ID
|
64344
ENSG00000186191
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
hypoxia inducible factor 3 subunit alpha
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasParalog
|
gptkb:HIF1A
HIF2A
|
|
gptkbp:HGNC_ID
|
HGNC:4896
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HIF3A
|
|
gptkbp:involvedIn
|
oxygen homeostasis
|
|
gptkbp:length
|
667 amino acids (canonical isoform)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
|
gptkbp:memberOf
|
hypoxia-inducible factor family
|
|
gptkbp:molecularWeight
|
~74 kDa (canonical isoform)
|
|
gptkbp:OMIM
|
610753
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Hif3a
|
|
gptkbp:proteinFamily
|
PAS domain
basic helix-loop-helix (bHLH)
|
|
gptkbp:regulates
|
yes
angiogenesis
cellular metabolism
erythropoiesis
VEGF expression
EPO expression
hypoxia-inducible genes
negative regulator of HIF1A and HIF2A activity
transcription under hypoxic conditions
|
|
gptkbp:UniProtID
|
Q9Y2N7
|
|
gptkbp:bfsParent
|
gptkb:Hypoxia-inducible_factor
gptkb:hypoxia-inducible_factor_(HIF)
gptkb:HIF-3α
|
|
gptkbp:bfsLayer
|
8
|