|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:death-inducing_signaling_complex_(DISC)
gptkb:Fas_receptor
gptkb:TNF_receptor
|
|
gptkbp:alias
|
gptkb:FLICE
gptkb:MACH
gptkb:Mch5
gptkb:CAP4
apoptotic cysteine protease 8
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:catalyzes
|
cleavage of aspartic acid residues
|
|
gptkbp:cleavage
|
18 kDa and 10 kDa subunits
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:EC_number
|
3.4.22.61
|
|
gptkbp:encodedBy
|
gptkb:CASP8_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:protease
initiator caspase in apoptosis
|
|
gptkbp:GO_term
|
GO:0004197 (cysteine-type endopeptidase activity)
GO:0006915 (apoptotic process)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
caspase-8 protein
|
|
gptkbp:inhibitedBy
|
gptkb:c-FLIP
z-IETD-fmk
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:caspase-3
gptkb:caspase-7
caspase-6
|
|
gptkbp:involvedIn
|
immune response
extrinsic apoptotic signaling pathway
|
|
gptkbp:locatedOnChromosome
|
chromosome 2q33-q34
|
|
gptkbp:molecularWeight
|
55 kDa (precursor)
|
|
gptkbp:OMIM
|
601763
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1QTN
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q14790
|
|
gptkbp:bfsParent
|
gptkb:CASP8
|
|
gptkbp:bfsLayer
|
8
|