Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
CASP8 and FADD-like apoptosis regulator
CFLAR |
| gptkbp:associatedWith |
gptkb:cancer
autoimmune diseases |
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
inhibits apoptosis
regulates caspase-8 activity |
| gptkbp:gene |
CFLAR gene
|
| gptkbp:hasIsoform |
c-FLIPL
c-FLIPR c-FLIPS |
| https://www.w3.org/2000/01/rdf-schema#label |
c-FLIP
|
| gptkbp:interactsWith |
gptkb:FADD
gptkb:caspase-8 |
| gptkbp:involvedIn |
extrinsic apoptotic signaling pathway
|
| gptkbp:locale |
gptkb:cell_membrane
gptkb:cytoplasm |
| gptkbp:locatedOnChromosome |
chromosome 2q33-q34
|
| gptkbp:molecularWeight |
55-55 kDa (isoform dependent)
|
| gptkbp:regulates |
cell survival
immune response NF-kappaB signaling death receptor signaling |
| gptkbp:structure |
contains pseudo-caspase domain
contains two DED domains |
| gptkbp:UniProtID |
O15519
|
| gptkbp:bfsParent |
gptkb:caspase-8
|
| gptkbp:bfsLayer |
7
|