Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
death receptor signaling
|
| gptkbp:alsoKnownAs |
gptkb:Caspase-8
|
| gptkbp:cleavage |
gptkb:caspase-3
gptkb:caspase-7 |
| gptkbp:discoveredIn |
1996
|
| gptkbp:encodedBy |
gptkb:CASP8_gene
|
| gptkbp:enzymeClassification |
EC 3.4.22.61
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
initiator caspase in apoptosis
mediates extrinsic apoptotic pathway |
| https://www.w3.org/2000/01/rdf-schema#label |
FLICE
|
| gptkbp:interactsWith |
gptkb:FADD
gptkb:TRADD |
| gptkbp:involvedIn |
immune response
cell death |
| gptkbp:mutationAssociatedWith |
gptkb:cancer
immunodeficiency |
| gptkbp:orthologIn |
Mus musculus (mouse)
|
| gptkbp:structure |
contains a caspase domain
contains two DED domains |
| gptkbp:bfsParent |
gptkb:caspase-8
|
| gptkbp:bfsLayer |
7
|