|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:FLICE
gptkb:MACH
gptkb:Mch5
gptkb:ALPS2B
gptkb:CAP4
CASP-8
CASPASE-8
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:autoimmune_lymphoproliferative_syndrome
gptkb:cancer
|
|
gptkbp:cleavage
|
active caspase-8
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
Caspase-8 protein
|
|
gptkbp:Entrez_Gene_ID
|
841
ENSG00000064012
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
apoptosis regulation
initiator caspase
|
|
gptkbp:HGNC_ID
|
HGNC:1509
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CASP8 gene
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:c-FLIP
gptkb:BID
gptkb:TRADD
TNFRSF6 (Fas receptor)
|
|
gptkbp:involvedIn
|
immune response
cell death
|
|
gptkbp:length
|
479 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
2q33-q34
|
|
gptkbp:mutationAssociatedWith
|
gptkb:neuroblastoma
gptkb:cancer
autoimmune disorders
colorectal cancer
hepatocellular carcinoma
esophageal squamous cell carcinoma
defective apoptosis
|
|
gptkbp:OMIM
|
601763
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Casp8
|
|
gptkbp:pathway
|
extrinsic apoptotic signaling pathway
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:product
|
gptkb:cysteine_protease
|
|
gptkbp:proteinFamily
|
gptkb:caspase_domain
gptkb:caspase_family
DED (Death Effector Domain)
|
|
gptkbp:regulates
|
gptkb:p53
gptkb:NF-κB
microRNAs
|
|
gptkbp:UniProtID
|
gptkb:Q14790
|
|
gptkbp:bfsParent
|
gptkb:caspase-8
|
|
gptkbp:bfsLayer
|
7
|