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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:MYC_protein
Avian myelocytomatosis viral oncogene homolog
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gptkbp:associatedWith
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gptkb:cancer
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gptkbp:binds
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E-box DNA sequence
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gptkbp:degradedBy
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gptkb:proteasome
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gptkbp:discoveredBy
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gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
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gptkbp:discoveredIn
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1979
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gptkbp:encodedBy
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gptkb:MYC_gene
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gptkbp:formsComplexWith
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gptkb:MAX_protein
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gptkbp:formsHeterodimerWith
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gptkb:MAX_protein
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gptkbp:foundIn
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gptkb:Homo_sapiens
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gptkbp:function
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transcription factor
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gptkbp:halfLife
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~20-30 minutes
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https://www.w3.org/2000/01/rdf-schema#label
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c-Myc protein
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gptkbp:involvedIn
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gptkb:neuroblastoma
gptkb:Burkitt_lymphoma
gptkb:cancer
colorectal cancer
leukemia
prostate cancer
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gptkbp:locale
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gptkb:nucleus
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gptkbp:locatedOnChromosome
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chromosome 8q24
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gptkbp:memberOf
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basic helix-loop-helix leucine zipper family
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gptkbp:molecularWeight
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~49 kDa
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gptkbp:orthologIn
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gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
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gptkbp:overexpressedIn
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tumorigenesis
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gptkbp:phosphorylates
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gptkb:Ser62
Thr58
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gptkbp:postTranslationalModification
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phosphorylation
ubiquitination
acetylation
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gptkbp:regulates
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apoptosis
metabolism
cell cycle progression
cell growth
DNA replication
cellular transformation
ribosome biogenesis
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gptkbp:structure
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contains bHLH-LZ domain
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gptkbp:target
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gptkb:siRNA
antisense oligonucleotides
small molecule inhibitors
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gptkbp:UniProtID
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P01106
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gptkbp:bfsParent
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gptkb:Myc
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gptkbp:bfsLayer
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6
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