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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alias
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gptkb:c-Myc
gptkb:MYCC
gptkb:bHLHe39
v-Myc (viral form)
|
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gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
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gptkbp:degradedBy
|
ubiquitin-proteasome system
Skp2
FBW7
|
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gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodedBy
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gptkb:MYC_gene
|
|
gptkbp:Entrez_Gene_ID
|
4609 (NCBI)
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
transcriptional activation
transcription factor
DNA binding
transcriptional repression
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MYC protein
|
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gptkbp:interactsWith
|
gptkb:MIZ-1_protein
gptkb:MAX_protein
SP1 protein
|
|
gptkbp:length
|
439 amino acids (human canonical isoform)
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
8q24.21 (human)
|
|
gptkbp:molecularWeight
|
48 kDa (approximate)
|
|
gptkbp:orthologIn
|
c-Myc (mouse)
dMyc (Drosophila)
|
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gptkbp:overexpressedIn
|
tumorigenesis
|
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gptkbp:PDB
|
1NKP
|
|
gptkbp:phosphorylates
|
gptkb:Ser62
Thr58
|
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gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:TGF-beta_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkb:Notch_signaling_pathway
gptkb:Wnt_signaling_pathway
apoptosis
cell differentiation
metabolism
cell growth
cell cycle
|
|
gptkbp:role
|
gptkb:neuroblastoma
gptkb:Burkitt_lymphoma
gptkb:cancer
colorectal cancer
leukemia
prostate cancer
Small Cell Lung Cancer
|
|
gptkbp:structure
|
contains basic helix-loop-helix leucine zipper domain
|
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gptkbp:target
|
gptkb:siRNA
antisense oligonucleotides
small molecule inhibitors
proteolysis targeting chimeras (PROTACs)
|
|
gptkbp:UniProtID
|
P01106
|
|
gptkbp:bfsParent
|
gptkb:MYC_gene
gptkb:HGNC:8583
gptkb:c-Myc_protein
gptkb:MAX_protein
gptkb:Threonine_58
|
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gptkbp:bfsLayer
|
7
|