|
gptkbp:instanceOf
|
gptkb:leukemia
gptkb:disease
|
|
gptkbp:affects
|
gptkb:B_cells
lymphatic system
|
|
gptkbp:associatedWith
|
gptkb:Epstein-Barr_virus
HIV infection
|
|
gptkbp:cellOrigin
|
germinal center B cell
|
|
gptkbp:characterizedBy
|
rapid growth
abdominal tumors (sporadic form)
jaw tumor (endemic form)
|
|
gptkbp:commonIn
|
gptkb:sub-Saharan_Africa
children
|
|
gptkbp:complication
|
gptkb:tumor_lysis_syndrome
|
|
gptkbp:diagnosedBy
|
biopsy
cytogenetic analysis
immunophenotyping
|
|
gptkbp:discoveredBy
|
gptkb:Denis_Burkitt
|
|
gptkbp:firstDescribed
|
1958
|
|
gptkbp:geneticAbnormality
|
t(8;14)(q24;q32) translocation
translocation of MYC gene
|
|
gptkbp:hasEpidemiology
|
more common in males
most common childhood cancer in equatorial Africa
rare in adults
|
|
gptkbp:hasTreatmentOutcome
|
cure possible with intensive therapy
|
|
gptkbp:ICD-10_code
|
C83.7
|
|
gptkbp:MeSH_ID
|
D002051
|
|
gptkbp:mortalityRate
|
high without treatment
|
|
gptkbp:namedAfter
|
gptkb:Denis_Burkitt
|
|
gptkbp:OMIM
|
113970
|
|
gptkbp:pathology
|
starry-sky appearance
|
|
gptkbp:prognosis
|
good with early treatment
|
|
gptkbp:riskFactor
|
immunosuppression
malaria
|
|
gptkbp:subspecies
|
endemic Burkitt lymphoma
immunodeficiency-associated Burkitt lymphoma
sporadic Burkitt lymphoma
|
|
gptkbp:symptom
|
fever
weight loss
night sweats
swelling
|
|
gptkbp:treatment
|
gptkb:rituximab
chemotherapy
|
|
gptkbp:WHOClassification
|
mature B-cell neoplasm
|
|
gptkbp:bfsParent
|
gptkb:Tcf3
gptkb:c-Myc
gptkb:Epstein-Barr_virus_infection
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Burkitt lymphoma
|