Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Oncology
|
| gptkbp:affects |
B cells
|
| gptkbp:associated_with |
EBV infection
|
| gptkbp:caused_by |
chromosomal translocation
|
| gptkbp:clinical_trial |
targeted therapies
ongoing research new therapies may involve the abdomen may involve the central nervous system often presents with jaw lesions rapid tumor growth |
| gptkbp:death |
varies by subtype
improved with early treatment generally favorable with aggressive treatment |
| gptkbp:diagnosis |
blood tests
imaging studies biopsy highly aggressive can be curable |
| gptkbp:discovered_by |
1940s
|
| gptkbp:epidemiology |
rare in developed countries
associated with endemic malaria more common in equatorial Africa |
| gptkbp:first_described_by |
Dorothy Burkitt
|
| gptkbp:genetic_studies |
MYC gene
BCL6 gene BCL2 gene |
| https://www.w3.org/2000/01/rdf-schema#label |
Burkitt lymphoma
|
| gptkbp:is_common_in |
gptkb:children
|
| gptkbp:named_after |
Dr. Denis Burkitt
|
| gptkbp:occurs_in |
higher in males
increased in certain regions |
| gptkbp:origin |
gptkb:Africa
gptkb:New_Guinea |
| gptkbp:research_focus |
environmental factors
genetic factors viral factors |
| gptkbp:risk_factor |
malaria
immunosuppression HIV infection |
| gptkbp:symptoms |
abdominal pain
fever night sweats swollen lymph nodes |
| gptkbp:treatment |
gptkb:immunotherapy
supportive care radiation therapy chemotherapy stem cell transplant depends on stage depends on age antiviral therapy depends on overall health CODOX-M regimen R-CHOP regimen high-dose methotrexate |
| gptkbp:type_of |
endemic Burkitt lymphoma
immunodeficiency-associated Burkitt lymphoma sporadic Burkitt lymphoma |
| gptkbp:bfsParent |
gptkb:Oncology
|
| gptkbp:bfsLayer |
4
|