Statements (46)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
leukemia |
| gptkbp:affects |
gptkb:B_cells
lymphatic system |
| gptkbp:associatedWith |
gptkb:Epstein-Barr_virus
HIV infection |
| gptkbp:cellOrigin |
germinal center B cell
|
| gptkbp:characterizedBy |
rapid growth
abdominal tumors (sporadic form) jaw tumor (endemic form) |
| gptkbp:commonIn |
gptkb:sub-Saharan_Africa
children |
| gptkbp:complication |
gptkb:tumor_lysis_syndrome
|
| gptkbp:diagnosedBy |
biopsy
cytogenetic analysis immunophenotyping |
| gptkbp:discoveredBy |
gptkb:Denis_Burkitt
|
| gptkbp:firstDescribed |
1958
|
| gptkbp:geneticAbnormality |
t(8;14)(q24;q32) translocation
translocation of MYC gene |
| gptkbp:hasEpidemiology |
more common in males
most common childhood cancer in equatorial Africa rare in adults |
| gptkbp:hasTreatmentOutcome |
cure possible with intensive therapy
|
| https://www.w3.org/2000/01/rdf-schema#label |
Burkitt lymphoma
|
| gptkbp:ICD-10_code |
C83.7
|
| gptkbp:MeSH_ID |
D002051
|
| gptkbp:mortalityRate |
high without treatment
|
| gptkbp:namedAfter |
gptkb:Denis_Burkitt
|
| gptkbp:OMIM |
113970
|
| gptkbp:pathology |
starry-sky appearance
|
| gptkbp:prognosis |
good with early treatment
|
| gptkbp:riskFactor |
immunosuppression
malaria |
| gptkbp:subspecies |
endemic Burkitt lymphoma
immunodeficiency-associated Burkitt lymphoma sporadic Burkitt lymphoma |
| gptkbp:symptom |
fever
weight loss night sweats swelling |
| gptkbp:treatment |
gptkb:rituximab
chemotherapy |
| gptkbp:WHOClassification |
mature B-cell neoplasm
|
| gptkbp:bfsParent |
gptkb:virus
|
| gptkbp:bfsLayer |
5
|