|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:c-Myc
gptkb:MYCC
gptkb:bHLHe39
gptkb:v-Myc
|
|
gptkbp:associatedWith
|
gptkb:Burkitt_lymphoma
gptkb:cancer
colorectal cancer
multiple myeloma
prostate cancer
|
|
gptkbp:discoveredBy
|
gptkb:Phillip_Leder
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodes
|
gptkb:MYC_protein
|
|
gptkbp:Entrez_Gene_ID
|
4609
ENSG00000136997
|
|
gptkbp:expressedIn
|
many tissues
tumor cells
|
|
gptkbp:formsComplexWith
|
gptkb:MIZ-1_protein
gptkb:MAX_protein
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
transcription factor
regulation of differentiation
|
|
gptkbp:HGNC_ID
|
7553
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MYC gene
|
|
gptkbp:locatedOnChromosome
|
8q24.21
|
|
gptkbp:mutationAssociatedWith
|
translocation
amplification
overexpression
|
|
gptkbp:OMIM
|
190080
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Myc_(mouse_gene)
gptkb:Myc_(rat_gene)
|
|
gptkbp:proteinFamily
|
gptkb:MYC_family
basic helix-loop-helix leucine zipper (bHLH-LZ)
|
|
gptkbp:regulates
|
gptkb:TGF-beta_pathway
gptkb:PI3K/AKT_pathway
gptkb:Notch_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:Wnt_signaling_pathway
metabolism
cellular senescence
angiogenesis
cell growth
DNA replication
cell cycle
epigenetic modifications
cell adhesion
ribosome biogenesis
microRNAs
transcription of target genes
stem cell self-renewal
|
|
gptkbp:target
|
gptkb:RNA_interference
therapeutic research
antisense oligonucleotides
small molecule inhibitors
|
|
gptkbp:UniProtID
|
P01106
|
|
gptkbp:bfsParent
|
gptkb:c-Myc
|
|
gptkbp:bfsLayer
|
6
|