|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD117
gptkb:mast/stem_cell_growth_factor_receptor_(SCFR)
gptkb:proto-oncogene_c-Kit
|
|
gptkbp:biologicalProcess
|
cell proliferation
signal transduction
cell migration
melanogenesis
protein tyrosine kinase activity
hematopoiesis
gametogenesis
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Tak_W._Mak
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodedBy
|
gptkb:KIT_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000157404
|
|
gptkbp:expressedIn
|
gptkb:melanocytes
gptkb:interstitial_cells_of_Cajal
gptkb:germ_cells
hematopoietic stem cells
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell differentiation
regulation of cell proliferation
cell signal transduction
|
|
gptkbp:gene
|
gptkb:KIT
|
|
gptkbp:HGNC_ID
|
HGNC:6342
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-KIT
|
|
gptkbp:ligand
|
gptkb:stem_cell_factor
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
|
|
gptkbp:memberOf
|
gptkb:type_III_receptor_tyrosine_kinase_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:gastrointestinal_stromal_tumor
gptkb:mastocytosis
gptkb:acute_myeloid_leukemia
piebladism
|
|
gptkbp:OMIM
|
164920
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
1T45
|
|
gptkbp:phosphorylates
|
tyrosine 568
tyrosine 570
tyrosine 703
tyrosine 721
tyrosine 936
|
|
gptkbp:relatedTo
|
gptkb:PDGFRA
gptkb:FLT3
gptkb:CSF1R
|
|
gptkbp:targetOfDrug
|
gptkb:imatinib
gptkb:regorafenib
gptkb:sunitinib
|
|
gptkbp:UniProtID
|
P10721
|
|
gptkbp:bfsParent
|
gptkb:imatinib_(Gleevec)
|
|
gptkbp:bfsLayer
|
6
|