|
gptkbp:instance_of
|
gptkb:protein
|
|
gptkbp:associated_with
|
gptkb:stem_cell_factor
|
|
gptkbp:breeding_range
|
4q12
|
|
gptkbp:clinical_trial
|
target for cancer therapy
marker for certain tumors
|
|
gptkbp:diseases
|
gptkb:myelodysplastic_syndromes
gptkb:neurofibromatosis_type_1
gptkb:Oncology
gptkb:pancreatic_cancer
gptkb:cervical_cancer
gptkb:mast_cell_activation_syndrome
ovarian cancer
liver cancer
esophageal cancer
bladder cancer
head and neck cancer
allergic diseases
sarcomas
leukemias
lymphomas
hypopigmentation disorders
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:genetic_studies
|
associated with acute myeloid leukemia (AML)
associated with mastocytosis
associated with gastrointestinal stromal tumors (GISTs)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-KIT
|
|
gptkbp:initiated_by
|
gptkb:imatinib
gptkb:sunitinib
gptkb:regorafenib
|
|
gptkbp:interacts_with
|
gptkb:FLT3
gptkb:PDGFR
|
|
gptkbp:involved_in
|
cell signaling
|
|
gptkbp:is_expressed_in
|
gptkb:hematopoietic_stem_cells
mast cells
germ cells
melanocytes
|
|
gptkbp:located_in
|
cell membrane
|
|
gptkbp:pathway
|
MAPK pathway
JAK/ STAT pathway
PI3 K/ AKT pathway
|
|
gptkbp:promoter
|
KIT
|
|
gptkbp:role
|
hematopoiesis
|
|
gptkbp:type
|
transmembrane protein
|
|
gptkbp:bfsParent
|
gptkb:imatinib_mesylate
gptkb:Pazopanib
|
|
gptkbp:bfsLayer
|
6
|