|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD135
FLK2
STK1
|
|
gptkbp:alternativeName
|
gptkb:CD135
|
|
gptkbp:associatedWith
|
gptkb:acute_myeloid_leukemia
gptkb:chronic_myelomonocytic_leukemia
leukemia
myelodysplastic syndrome
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
protein tyrosine kinase activity
hematopoiesis
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
Small D et al.
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
FLT3 protein
|
|
gptkbp:Entrez_Gene_ID
|
2322
ENSG00000122025
|
|
gptkbp:expressedIn
|
hematopoietic progenitor cells
|
|
gptkbp:fullName
|
gptkb:Fms-like_tyrosine_kinase_3
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:3765
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FLT3
|
|
gptkbp:length
|
24 exons
|
|
gptkbp:locatedOnChromosome
|
13
13q12.2
|
|
gptkbp:mutationAssociatedWith
|
internal tandem duplication
tyrosine kinase domain mutation
|
|
gptkbp:OMIM
|
136351
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Flt3
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:proteinFamily
|
class III receptor tyrosine kinase
|
|
gptkbp:regulates
|
FLT3 ligand
|
|
gptkbp:symbol
|
gptkb:FLT3
|
|
gptkbp:target
|
gptkb:gilteritinib
gptkb:quizartinib
gptkb:midostaurin
|
|
gptkbp:UniProtID
|
P36888
|
|
gptkbp:bfsParent
|
gptkb:FLT3_mutation
gptkb:midostaurin
|
|
gptkbp:bfsLayer
|
6
|