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gptkbp:instanceOf
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gptkb:protein
cytokine
|
|
gptkbp:alternativeName
|
gptkb:SCF
gptkb:mast_cell_growth_factor
gptkb:steel_factor
c-kit ligand
|
|
gptkbp:associatedWith
|
gptkb:mastocytosis
gptkb:anemia
infertility
piebladism
|
|
gptkbp:biologicalProcess
|
melanogenesis
hematopoiesis
gametogenesis
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodedBy
|
gptkb:KITLG_gene
|
|
gptkbp:Entrez_Gene_ID
|
4254
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skin
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:small_intestine
gptkb:testis
brain
heart
spleen
colon
pancreas
endothelial cells
fibroblasts
fetal liver
bone marrow stromal cells
|
|
gptkbp:function
|
promotes differentiation of hematopoietic progenitor cells
stimulates hematopoietic stem cell proliferation
supports survival of hematopoietic stem cells
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
stem cell factor
|
|
gptkbp:locatedOnChromosome
|
chromosome 12q22
|
|
gptkbp:location
|
gptkb:cell_membrane
extracellular space
|
|
gptkbp:medicalUse
|
used in stem cell mobilization
|
|
gptkbp:molecularWeight
|
~30 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause infertility
can cause anemia
can cause piebaldism
|
|
gptkbp:OMIM
|
184745
|
|
gptkbp:orthologIn
|
mouse Kitl
|
|
gptkbp:recipient
|
gptkb:c-Kit
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:UniProtID
|
P21583
|
|
gptkbp:bfsParent
|
gptkb:Sertoli_cells
|
|
gptkbp:bfsLayer
|
6
|