|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:FMS
CD115
M-CSF receptor
|
|
gptkbp:associatedWith
|
gptkb:cancer
adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)
leukoencephalopathy with spheroids
|
|
gptkbp:discoveredBy
|
gptkb:Sherr_CJ
|
|
gptkbp:domain
|
immunoglobulin-like domain
tyrosine kinase domain
|
|
gptkbp:encodes
|
CSF1R protein
|
|
gptkbp:Entrez_Gene_ID
|
1436
ENSG00000182578
|
|
gptkbp:expressedIn
|
gptkb:microglia
macrophages
monocytes
|
|
gptkbp:fullName
|
colony stimulating factor 1 receptor
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds colony stimulating factor 1
binds interleukin-34
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
2443
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CSF1R
|
|
gptkbp:involvedIn
|
immune response
macrophage differentiation
monocyte proliferation
|
|
gptkbp:ligand
|
CSF1
IL-34
|
|
gptkbp:locatedOnChromosome
|
5
5q32
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~150 kDa
|
|
gptkbp:mutationAssociatedWith
|
ALSP
hereditary diffuse leukoencephalopathy with spheroids
|
|
gptkbp:OMIM
|
164770
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Csf1r
|
|
gptkbp:PDB
|
4R7H
|
|
gptkbp:phosphorylates
|
Y561
Y699
Y807
Y921
Y974
|
|
gptkbp:proteinFamily
|
PDGF receptor family
|
|
gptkbp:regulates
|
cell proliferation
cell survival
differentiation
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:target
|
tyrosine kinase inhibitors
|
|
gptkbp:transmembraneDomains
|
true
|
|
gptkbp:UniProtID
|
P07333
|
|
gptkbp:bfsParent
|
gptkb:c-KIT
gptkb:RUNX1
|
|
gptkbp:bfsLayer
|
7
|