Vascular Endothelial Growth Factor Receptor

URI: https://gptkb.org/entity/Vascular_Endothelial_Growth_Factor_Receptor
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:VEGFR
gptkbp:activatedBy gptkb:VEGF-A
gptkb:VEGF-B
gptkb:VEGF-C
gptkb:VEGF-D
placenta growth factor
gptkbp:binds gptkb:vascular_endothelial_growth_factor
gptkbp:discoveredIn 1990s
gptkbp:expressedIn endothelial cells
gptkbp:foundIn vertebrates
gptkbp:function gptkb:receptor_tyrosine_kinase
gptkbp:gene gptkb:FLT1
gptkb:FLT4
gptkb:KDR
https://www.w3.org/2000/01/rdf-schema#label Vascular Endothelial Growth Factor Receptor
gptkbp:inhibitedBy gptkb:bevacizumab
gptkb:sorafenib
gptkb:pazopanib
gptkb:sunitinib
gptkb:axitinib
gptkb:ramucirumab
gptkbp:involvedIn angiogenesis
vasculogenesis
gptkbp:involves gptkb:cancer
age-related macular degeneration
diabetic retinopathy
gptkbp:locale gptkb:cell_membrane
gptkbp:memberOf receptor tyrosine kinase family
gptkbp:OMIM 192240
gptkbp:role embryonic development
wound healing
tumor growth
blood vessel formation
lymphangiogenesis
gptkbp:structure transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
gptkbp:subspecies gptkb:VEGFR-1
gptkb:VEGFR-2
gptkb:VEGFR-3
gptkbp:target anti-angiogenic drugs
gptkbp:UniProtID P17948
P35968
P35916
gptkbp:bfsParent gptkb:VEGFR
gptkbp:bfsLayer 6