Vascular Endothelial Growth Factor Receptor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:VEGFR
gptkbp:activatedBy	gptkb:VEGF-A gptkb:VEGF-B gptkb:VEGF-C gptkb:VEGF-D placenta growth factor
gptkbp:binds	gptkb:vascular_endothelial_growth_factor
gptkbp:discoveredIn	1990s
gptkbp:expressedIn	endothelial cells
gptkbp:foundIn	vertebrates
gptkbp:function	gptkb:receptor_tyrosine_kinase
gptkbp:gene	gptkb:FLT1 gptkb:FLT4 gptkb:KDR
gptkbp:inhibitedBy	gptkb:bevacizumab gptkb:sorafenib gptkb:pazopanib gptkb:sunitinib gptkb:axitinib gptkb:ramucirumab
gptkbp:involvedIn	angiogenesis vasculogenesis
gptkbp:involves	gptkb:age-related_macular_degeneration gptkb:cancer diabetic retinopathy
gptkbp:locale	gptkb:cell_membrane
gptkbp:memberOf	receptor tyrosine kinase family
gptkbp:OMIM	192240
gptkbp:role	embryonic development wound healing tumor growth blood vessel formation lymphangiogenesis
gptkbp:structure	transmembrane domain extracellular ligand-binding domain intracellular tyrosine kinase domain
gptkbp:subspecies	gptkb:VEGFR-1 gptkb:VEGFR-2 gptkb:VEGFR-3
gptkbp:target	anti-angiogenic drugs
gptkbp:UniProtID	P17948 P35968 P35916
gptkbp:bfsParent	gptkb:VEGFR
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Vascular Endothelial Growth Factor Receptor