|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:FLT4
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:discoveredBy
|
Kari Alitalo
|
|
gptkbp:domain
|
tyrosine kinase domain
immunoglobulin-like domains
|
|
gptkbp:encodedBy
|
gptkb:FLT4_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000137098
2324
|
|
gptkbp:expressedIn
|
embryonic development
lymphatic endothelial cells
some tumor cells
|
|
gptkbp:function
|
regulation of angiogenesis
regulation of lymphangiogenesis
|
|
gptkbp:gene
|
gptkb:FLT4
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3767
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGFR-3
|
|
gptkbp:inhibitedBy
|
gptkb:Lenvatinib
gptkb:Regorafenib
gptkb:Sorafenib
gptkb:Axitinib
gptkb:Sunitinib
MAZ51
SAR131675
|
|
gptkbp:involves
|
gptkb:hereditary_lymphedema
cancer metastasis
tumor lymphangiogenesis
|
|
gptkbp:ligand
|
gptkb:VEGF-C
gptkb:VEGF-D
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5q35.3
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
receptor tyrosine kinase family
VEGF receptor family
|
|
gptkbp:molecularWeight
|
195 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Milroy_disease
frameshift mutations
missense mutations
nonsense mutations
|
|
gptkbp:OMIM
|
136352
|
|
gptkbp:orthologInMouse
|
Flt4
|
|
gptkbp:PDB
|
4BSK
|
|
gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:structure
|
transmembrane protein
|
|
gptkbp:target
|
anti-lymphangiogenic therapies
|
|
gptkbp:type
|
activates MAPK pathway
activates PI3K/AKT pathway
activates PLCĪ³ pathway
|
|
gptkbp:UniProtID
|
P35916
|
|
gptkbp:bfsParent
|
gptkb:VEGFR
|
|
gptkbp:bfsLayer
|
6
|