Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
protein
|
| gptkbp:associatedWith |
gptkb:pulmonary_hypertension
tumor growth atherosclerosis rheumatoid arthritis diabetic retinopathy age-related macular degeneration |
| gptkbp:clinicalTrials |
target for cancer therapy
|
| gptkbp:community |
regulated by cytokines
regulated by hypoxia found in endothelial cells |
| gptkbp:culturalEvents |
found in multiple species
|
| gptkbp:function |
binds to vascular endothelial growth factor (VEGF)
|
| gptkbp:geneticDiversity |
FLT1
associated with various diseases |
| https://www.w3.org/2000/01/rdf-schema#label |
VEGFR-1
|
| gptkbp:interactsWith |
VEGF-A
VEGF-B |
| gptkbp:involvedIn |
cell differentiation
cell proliferation immune response inflammation wound healing cell survival tumor microenvironment extracellular matrix remodeling vascular homeostasis cancer progression neurogenesis vascular permeability vascular remodeling placental development tissue repair neuroprotection cell adhesion cell migration metastasis neurovascular unit tumor angiogenesis endothelial cell function immune evasion neovascularization hypoxia response tumor microenvironment modulation angiogenic switch blood-brain barrier integrity cardiovascular development lymphangiogenesis |
| gptkbp:is_a_route_for |
VEGF signaling pathway
|
| gptkbp:isActiveIn |
VEGF-mediated endothelial cell proliferation
VEGFR-1_inhibitors |
| gptkbp:location |
cell membrane
|
| gptkbp:promotes |
survival of endothelial cells
|
| gptkbp:releaseYear |
1993
|
| gptkbp:research_areas |
monoclonal antibodies
small molecule inhibitors anti-VEGF therapies |
| gptkbp:role |
regulates angiogenesis
|
| gptkbp:type |
receptor tyrosine kinase
|