Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:receptor_tyrosine_kinase
gptkb:protein |
| gptkbp:alternativeName |
Flt-1
vascular endothelial growth factor receptor 1 |
| gptkbp:binds |
gptkb:VEGF-A
gptkb:VEGF-B gptkb:placental_growth_factor_(PlGF) |
| gptkbp:discoveredBy |
gptkb:Napoleone_Ferrara
|
| gptkbp:discoveredIn |
1992
|
| gptkbp:domain |
tyrosine kinase domain
immunoglobulin-like domains |
| gptkbp:encodedBy |
gptkb:FLT1_gene
|
| gptkbp:expressedIn |
macrophages
endothelial cells monocytes |
| gptkbp:function |
angiogenesis regulation
vascular permeability regulation |
| gptkbp:HGNC_ID |
HGNC:3763
|
| https://www.w3.org/2000/01/rdf-schema#label |
VEGFR-1
|
| gptkbp:inhibitedBy |
gptkb:bevacizumab
gptkb:aflibercept gptkb:ranibizumab |
| gptkbp:involvedIn |
gptkb:cancer
retinal diseases pre-eclampsia |
| gptkbp:isSolubleIn |
sFlt-1
|
| gptkbp:locatedIn |
gptkb:cell_membrane
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_13q12
|
| gptkbp:OMIM |
165070
|
| gptkbp:UniProtID |
P17948
|
| gptkbp:bfsParent |
gptkb:VEGFR
gptkb:Vascular_endothelial_growth_factor_A |
| gptkbp:bfsLayer |
6
|