|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:KDR
gptkb:CD309
gptkb:Flk-1
|
|
gptkbp:associatedWith
|
metastasis
tumor growth
|
|
gptkbp:discoveredBy
|
gptkb:Napoleone_Ferrara
|
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gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
gptkb:KDR_gene
|
|
gptkbp:Entrez_Gene_ID
|
3791
|
|
gptkbp:expressedIn
|
endothelial cells
|
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gptkbp:foundIn
|
gptkb:Homo_sapiens
|
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gptkbp:function
|
regulates angiogenesis
mediates vascular endothelial growth factor (VEGF) signaling
regulates vascular permeability
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGFR-2
|
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gptkbp:inhibitedBy
|
gptkb:sorafenib
gptkb:pazopanib
gptkb:sunitinib
gptkb:axitinib
gptkb:ramucirumab
|
|
gptkbp:ligand
|
gptkb:VEGF-A
gptkb:VEGF-C
gptkb:VEGF-D
|
|
gptkbp:locatedOn
|
gptkb:chromosome_4q12
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
approximately 200-230 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hereditary_hemorrhagic_telangiectasia
infantile capillary hemangioma
|
|
gptkbp:OMIM
|
191306
|
|
gptkbp:orthologInMouse
|
gptkb:Flk-1
|
|
gptkbp:PDB
|
3V2A
2OH4
4ASD
|
|
gptkbp:phosphorylates
|
Tyr1175
Tyr1214
Tyr951
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
ubiquitination
|
|
gptkbp:role
|
vasculogenesis
embryonic blood vessel formation
|
|
gptkbp:structure
|
contains 7 immunoglobulin-like domains
has a single transmembrane domain
has an intracellular tyrosine kinase domain
|
|
gptkbp:target
|
anti-angiogenic cancer therapies
|
|
gptkbp:UniProtID
|
P35968
|
|
gptkbp:bfsParent
|
gptkb:VEGFR
gptkb:Vascular_endothelial_growth_factor_A
gptkb:KDR
|
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gptkbp:bfsLayer
|
6
|