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gptkbp:instanceOf
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gptkb:gene
|
|
gptkbp:alternativeName
|
Fms-related tyrosine kinase 1
vascular endothelial growth factor receptor 1
|
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gptkbp:associatedWith
|
gptkb:cancer
angiogenesis
pre-eclampsia
|
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gptkbp:biologicalProcess
|
cell proliferation
cell migration
protein tyrosine kinase activity
blood vessel development
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
extracellular region
|
|
gptkbp:discoveredBy
|
gptkb:Shibuya_et_al.
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodes
|
VEGFR1 protein
|
|
gptkbp:Entrez_Gene_ID
|
2321
ENSG00000102755
|
|
gptkbp:expressedIn
|
gptkb:placenta
endothelial cells
monocytes
|
|
gptkbp:function
|
receptor for VEGF-A, VEGF-B, and PlGF
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
rs7993418
rs9582036
|
|
gptkbp:hasTranscriptVariant
|
soluble FLT1 (sFLT1)
|
|
gptkbp:HGNC_ID
|
HGNC:3763
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FLT1
|
|
gptkbp:involvedIn
|
tumor angiogenesis
pre-eclampsia pathogenesis
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_13
|
|
gptkbp:OMIM
|
165070
|
|
gptkbp:orthologInMouse
|
Flt1
|
|
gptkbp:proteinFamily
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:regulates
|
vascular permeability
endothelial cell function
|
|
gptkbp:significance
|
biomarker for pre-eclampsia
therapeutic target in cancer
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:target
|
anti-angiogenic drugs
|
|
gptkbp:UniProtID
|
P17948
|
|
gptkbp:bfsParent
|
gptkb:VEGFR
gptkb:VEGFR1
|
|
gptkbp:bfsLayer
|
6
|