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gptkbp:instanceOf
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gptkb:gene
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gptkbp:alternativeName
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Fms-related tyrosine kinase 1
vascular endothelial growth factor receptor 1
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gptkbp:associatedWith
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gptkb:cancer
angiogenesis
pre-eclampsia
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gptkbp:biologicalProcess
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angiogenesis
cell signaling
receptor tyrosine kinase activity
vasculogenesis
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gptkbp:cellularComponent
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gptkb:plasma_membrane
extracellular region
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gptkbp:discoveredBy
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gptkb:Shibuya_et_al.
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gptkbp:encodes
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VEGFR1 protein
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gptkbp:Entrez_Gene_ID
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2321
ENSG00000102755
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gptkbp:expressedIn
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endothelial cells
high in placenta
high in vascular endothelium
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gptkbp:firstDescribed
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1990
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gptkbp:function
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receptor for VEGF-A, VEGF-B, and PlGF
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gptkbp:hasIsoform
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soluble FLT1 (sFLT1)
membrane-bound FLT1
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gptkbp:hasTranscriptVariant
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multiple
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gptkbp:HGNC_ID
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HGNC:3763
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https://www.w3.org/2000/01/rdf-schema#label
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FLT1 gene
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gptkbp:interactsWith
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gptkb:VEGF-A
gptkb:VEGF-B
gptkb:PlGF
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gptkbp:length
|
1338 amino acids
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gptkbp:locatedOnChromosome
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gptkb:13q12
gptkb:chromosome_13
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gptkbp:mutationAssociatedWith
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vascular diseases
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gptkbp:OMIM
|
165070
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologInMouse
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Flt1
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gptkbp:pathway
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gptkb:VEGF_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
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gptkbp:product
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gptkb:VEGFR1
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gptkbp:proteinFamily
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tyrosine kinase domain
immunoglobulin-like domains
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gptkbp:regulates
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endothelial cell proliferation
regulated by HIF1A
upregulated by hypoxia
vascular permeability
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gptkbp:significance
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target for anti-angiogenic therapy
biomarker for pre-eclampsia
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gptkbp:UniProtID
|
P17948
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gptkbp:bfsParent
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gptkb:VEGFR1
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gptkbp:bfsLayer
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6
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