Fms-like tyrosine kinase 1

URI: https://gptkb.org/entity/Fms-like_tyrosine_kinase_1
GPTKB entity
Statements (31)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alternativeName gptkb:VEGFR-1
vascular endothelial growth factor receptor 1
gptkbp:associatedWith preeclampsia
gptkbp:binds gptkb:VEGF-A
gptkb:VEGF-B
placenta growth factor (PlGF)
gptkbp:biologicalProcess protein tyrosine kinase activity
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:discoveredBy gptkb:Shibuya_et_al.
gptkbp:discoveredIn 1990
gptkbp:encodedBy gptkb:FLT1_gene
gptkbp:Entrez_Gene_ID 2321
ENSG00000102755
gptkbp:expressedIn endothelial cells
gptkbp:function involved in angiogenesis
regulates vascular permeability
receptor for vascular endothelial growth factor (VEGF)
gptkbp:hasIsoform soluble FLT1 (sFLT1)
gptkbp:HGNC_ID HGNC:3763
https://www.w3.org/2000/01/rdf-schema#label Fms-like tyrosine kinase 1
gptkbp:locatedOnChromosome gptkb:chromosome_13
gptkbp:OMIM 165070
gptkbp:organism gptkb:Homo_sapiens
gptkbp:significance target for anti-angiogenic therapy
biomarker for preeclampsia
gptkbp:symbol gptkb:FLT1
gptkbp:UniProtID P17948
gptkbp:bfsParent gptkb:VEGFR1
gptkbp:bfsLayer 6