Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
sFlt-1
soluble fms-like tyrosine kinase-1 |
| gptkbp:associatedWith |
preeclampsia
|
| gptkbp:biologicalProcess |
regulation of angiogenesis
|
| gptkbp:category |
angiogenesis inhibitor
soluble receptor |
| gptkbp:derivedFrom |
VEGFR1 gene
|
| gptkbp:elevatedIn |
heart failure
chronic kidney disease preeclampsia |
| gptkbp:encodedBy |
gptkb:FLT1_gene
|
| gptkbp:function |
acts as a decoy receptor
binds placental growth factor (PlGF) binds vascular endothelial growth factor (VEGF) |
| https://www.w3.org/2000/01/rdf-schema#label |
soluble VEGFR1 (sFlt-1)
|
| gptkbp:inhibitedBy |
VEGF signaling
PlGF signaling |
| gptkbp:location |
blood plasma
|
| gptkbp:medicalUse |
biomarker for preeclampsia
|
| gptkbp:molecularWeight |
~100 kDa
|
| gptkbp:producedBy |
alternative splicing of FLT1 mRNA
|
| gptkbp:bfsParent |
gptkb:VEGFR1
|
| gptkbp:bfsLayer |
6
|