|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
immune response
|
|
gptkbp:discoveredBy
|
1989
|
|
gptkbp:domain
|
gptkb:PH_domain
gptkb:EF-hand_domain
SH2 domain
SH3 domain
|
|
gptkbp:encodedBy
|
PLCG1 gene
|
|
gptkbp:fullName
|
Phospholipase C gamma 1
|
|
gptkbp:function
|
generates second messengers IP3 and DAG
hydrolyzes phosphatidylinositol 4,5-bisphosphate
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLC-gamma1
|
|
gptkbp:interactsWith
|
gptkb:EGFR
gptkb:FGFR1
gptkb:PI3K
gptkb:Grb2
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
signal transduction
cell motility
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
20q12-q13.1
|
|
gptkbp:molecularWeight
|
~150 kDa
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:phosphorylates
|
gptkb:Src_family_kinases
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
P19174
|
|
gptkbp:bfsParent
|
gptkb:T-cell_receptor_signaling_pathway
gptkb:T_cell_receptor_signaling_pathway
gptkb:Linker_for_activation_of_T_cells_protein
|
|
gptkbp:bfsLayer
|
8
|