Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
guanine nucleotide exchange factors (GEFs)
|
| gptkbp:decommissioned |
GTPase-activating proteins (GAPs)
|
| gptkbp:discoveredBy |
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop |
| gptkbp:downstreamOf |
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway gptkb:receptor_tyrosine_kinases |
| gptkbp:encodedBy |
gptkb:HRAS
gptkb:KRAS gptkb:NRAS |
| gptkbp:firstDescribed |
1980s
|
| gptkbp:form |
GTP-bound
|
| gptkbp:function |
guanine nucleotide exchange factor
|
| https://www.w3.org/2000/01/rdf-schema#label |
Ras
|
| gptkbp:inactiveForm |
GDP-bound
|
| gptkbp:involvedIn |
cell signaling
|
| gptkbp:location |
inner surface of plasma membrane
|
| gptkbp:memberOf |
gptkb:small_GTPase_superfamily
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
|
| gptkbp:nameOrigin |
gptkb:rat_sarcoma_virus
|
| gptkbp:regulates |
cell differentiation
cell survival cell growth |
| gptkbp:bfsParent |
gptkb:King
|
| gptkbp:bfsLayer |
4
|