|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD152
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
Graves' disease
type 1 diabetes
autoimmune diseases
rheumatoid arthritis
|
|
gptkbp:biologicalProcess
|
immune response
receptor activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Pierre_Golstein
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodes
|
gptkb:CTLA-4_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000163599
1493
|
|
gptkbp:expressedIn
|
activated T cells
|
|
gptkbp:fullName
|
gptkb:Cytotoxic_T-lymphocyte-associated_protein_4
|
|
gptkbp:function
|
negative regulator of T-cell immune responses
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
2504
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CTLA4 gene
|
|
gptkbp:inhibitedBy
|
CD28-mediated co-stimulation
|
|
gptkbp:interactsWith
|
gptkb:CD80
gptkb:CD86
|
|
gptkbp:length
|
4 exons
|
|
gptkbp:lengthOfProtein
|
223 amino acids
|
|
gptkbp:locatedOnChromosome
|
2
2q33.2
|
|
gptkbp:mutationAssociatedWith
|
gptkb:CTLA4_deficiency
immune dysregulation
|
|
gptkbp:OMIM
|
123890
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Ctla4
|
|
gptkbp:pathway
|
gptkb:T_cell_receptor_signaling_pathway
immune checkpoint pathway
|
|
gptkbp:PDB
|
gptkb:1I8L
|
|
gptkbp:proteinFamily
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:regulates
|
T cell activation
|
|
gptkbp:reviewedBy
|
gptkb:GeneReviews
gptkb:NCBI_Gene
gptkb:UniProtKB
|
|
gptkbp:significance
|
immunotherapy target
|
|
gptkbp:symbol
|
gptkb:CTLA4
|
|
gptkbp:target
|
gptkb:abatacept
gptkb:belatacept
gptkb:ipilimumab
|
|
gptkbp:UniProtID
|
P16410
|
|
gptkbp:bfsParent
|
gptkb:CTLA-4
|
|
gptkbp:bfsLayer
|
6
|