|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:PTP-1C
gptkb:PTP1C
gptkb:TCPTP
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Crohn's_disease
type 1 diabetes
ulcerative colitis
autoimmune diseases
|
|
gptkbp:biologicalProcess
|
signal transduction
phosphatase activity
immune system process
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
gptkb:Tonks_NK
|
|
gptkbp:encodes
|
gptkb:Tyrosine-protein_phosphatase_non-receptor_type_2
|
|
gptkbp:Entrez_Gene_ID
|
5771
ENSG00000169047
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
gptkb:thymus
liver
spleen
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:function
|
regulation of cell growth
protein tyrosine phosphatase activity
negative regulation of cytokine signaling
regulation of immune response
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
PTPN2-201
PTPN2-202
PTPN2-203
PTPN2-204
PTPN2-205
|
|
gptkbp:HGNC_ID
|
9640
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTPN2
|
|
gptkbp:length
|
10 exons
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_18
|
|
gptkbp:mutationAssociatedWith
|
autoimmunity
inflammatory bowel disease
|
|
gptkbp:OMIM
|
176887
|
|
gptkbp:orthologInMouse
|
gptkb:Ptpn2
|
|
gptkbp:proteinFamily
|
gptkb:protein_tyrosine_phosphatase_family
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:T_cell_receptor_signaling_pathway
gptkb:JAK/STAT_signaling_pathway
insulin signaling pathway
|
|
gptkbp:UniProtID
|
P17706
|
|
gptkbp:bfsParent
|
gptkb:protein_tyrosine_phosphatases
|
|
gptkbp:bfsLayer
|
6
|