|
gptkbp:instanceOf
|
gptkb:protein
ion channel
|
|
gptkbp:activatedBy
|
gptkb:protons
gptkb:capsaicin
gptkb:allyl_isothiocyanate
gptkb:resiniferatoxin
heat
|
|
gptkbp:affiliatedWith
|
gptkb:TRPV_subfamily
gptkb:TRP_channel_family
|
|
gptkbp:alsoKnownAs
|
gptkb:capsaicin_receptor
gptkb:transient_receptor_potential_cation_channel_subfamily_V_member_1
|
|
gptkbp:discoveredBy
|
gptkb:David_Julius
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodedBy
|
gptkb:TRPV1_gene
|
|
gptkbp:expressedIn
|
gptkb:dorsal_root_ganglion
gptkb:trigeminal_ganglion
|
|
gptkbp:foundIn
|
sensory neurons
|
|
gptkbp:function
|
detects noxious heat
mediates pain perception
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TRPV1 receptor
|
|
gptkbp:inhibitedBy
|
gptkb:capsazepine
gptkb:ruthenium_red
|
|
gptkbp:involves
|
chronic pain
migraine
inflammatory bowel disease
cough reflex
bladder disorders
|
|
gptkbp:locatedOn
|
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17p13.2_(human)
|
|
gptkbp:modulatedBy
|
gptkb:calmodulin
gptkb:protein_kinase_C
gptkb:anandamide
gptkb:PIP2
gptkb:protein_kinase_A
gptkb:endovanilloids
phosphorylation
arachidonic acid metabolites
|
|
gptkbp:molecularWeight
|
~95 kDa
|
|
gptkbp:permeableTo
|
magnesium ions
calcium ions
sodium ions
|
|
gptkbp:role
|
peripheral neuropathy
inflammatory pain
thermal hyperalgesia
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:target
|
analgesic drugs
topical capsaicin creams
|
|
gptkbp:transmembraneDomains
|
6
|
|
gptkbp:UniProtID
|
gptkb:Q8NER1
|
|
gptkbp:bfsParent
|
gptkb:capsaicin
gptkb:Capsaicin
|
|
gptkbp:bfsLayer
|
5
|