|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:protons
gptkb:capsaicin
heat
|
|
gptkbp:alternativeName
|
gptkb:capsaicin_receptor
gptkb:transient_receptor_potential_cation_channel_subfamily_V_member_1
|
|
gptkbp:associatedWith
|
asthma
peripheral neuropathy
chronic pain
migraine
inflammatory response
inflammatory bowel disease
pain perception
thermal nociception
|
|
gptkbp:discoveredBy
|
gptkb:David_Julius
|
|
gptkbp:encodes
|
TRPV1 protein
|
|
gptkbp:Entrez_Gene_ID
|
7442
ENSG00000196689
|
|
gptkbp:expressedIn
|
gptkb:skin
gptkb:urinary_bladder
gptkb:dorsal_root_ganglia
brain
sensory neurons
trigeminal ganglia
|
|
gptkbp:firstDescribed
|
1997
|
|
gptkbp:form
|
tetrameric channel
|
|
gptkbp:function
|
mediates pain and heat sensation
non-selective cation channel
|
|
gptkbp:HGNC_ID
|
HGNC:17992
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TRPV1 gene
|
|
gptkbp:length
|
16,434 base pairs
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
|
|
gptkbp:locusType
|
gptkb:17p13.2
|
|
gptkbp:modulatedBy
|
gptkb:anandamide
gptkb:capsazepine
gptkb:endovanilloids
gptkb:resiniferatoxin
prostaglandins
|
|
gptkbp:mutationAssociatedWith
|
altered pain sensitivity
increased risk of chronic pain
reduced thermal nociception
|
|
gptkbp:OMIM
|
602076
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:proteinFamily
|
gptkb:TRP_channel_family
|
|
gptkbp:proteinSubfamily
|
gptkb:TRPV_subfamily
|
|
gptkbp:structure
|
six transmembrane domains
|
|
gptkbp:target
|
anti-inflammatory drugs
analgesic drugs
neuropathic pain therapies
|
|
gptkbp:UniProtID
|
gptkb:Q8NER1
|
|
gptkbp:bfsParent
|
gptkb:TRPV1_receptor
|
|
gptkbp:bfsLayer
|
6
|