|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:abnormal_activity_associated_with
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:activatedBy
|
phorbol esters
calcium ions
diacylglycerol
|
|
gptkbp:cofactor
|
gptkb:ATP
phospholipids
|
|
gptkbp:discoveredBy
|
gptkb:Yasutomi_Nishizuka
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:EC_number
|
2.7.11.13
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:familyMember
|
gptkb:PKC_alpha
gptkb:PKC_beta
gptkb:PKC_delta
gptkb:PKC_epsilon
gptkb:PKC_eta
gptkb:PKC_gamma
gptkb:PKC_theta
gptkb:PKC_zeta
PKC iota/lambda
|
|
gptkbp:function
|
phosphorylation of serine and threonine residues
|
|
gptkbp:inhibitedBy
|
gptkb:chelerythrine
gptkb:staurosporine
|
|
gptkbp:locatedIn
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:role
|
gptkb:immune_response
apoptosis
cell proliferation
differentiation
signal transduction
cancer progression
neuronal signaling
cardiovascular function
|
|
gptkbp:structure
|
gptkb:C1_domain
regulatory domain
C2 domain
catalytic domain
C3 domain
C4 domain
|
|
gptkbp:substrate
|
gptkb:histone_H1
gptkb:GAP-43
gptkb:myristoylated_alanine-rich_C-kinase_substrate
MARCKS protein
|
|
gptkbp:bfsParent
|
gptkb:14-3-3_proteins
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
protein kinase C
|