|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
CaM
|
|
gptkbp:binds
|
calcium ions
|
|
gptkbp:conservedIn
|
yes
|
|
gptkbp:discoveredIn
|
1970
|
|
gptkbp:domain
|
EF-hand motif
|
|
gptkbp:encodedBy
|
CALM1 gene
CALM2 gene
CALM3 gene
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
signal transduction
calcium binding
|
|
gptkbp:GO
|
gptkb:GO:0005509
|
|
gptkbp:interactsWith
|
gptkb:myosin_light-chain_kinase
gptkb:ryanodine_receptor
gptkb:CaMKII
adenylyl cyclase
phosphodiesterase
voltage-gated calcium channels
calcineurin
inositol trisphosphate receptor
|
|
gptkbp:length
|
148
|
|
gptkbp:locale
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
human chromosome 14 (CALM1)
human chromosome 19 (CALM3)
human chromosome 2 (CALM2)
|
|
gptkbp:molecularWeight
|
16.7 kDa
|
|
gptkbp:OMIM
|
114180
|
|
gptkbp:PDB
|
1CLL
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
acetylation
|
|
gptkbp:regulates
|
gptkb:myosin_light-chain_kinase
ion channels
protein kinases
phosphatases
phosphodiesterases
Ca2+/calmodulin-dependent protein kinase II
adenylyl cyclases
|
|
gptkbp:requires
|
gptkb:synaptic_plasticity
cell cycle progression
muscle contraction
memory formation
|
|
gptkbp:significance
|
mutations linked to cardiac arrhythmias
mutations linked to long QT syndrome
mutations linked to sudden cardiac death
|
|
gptkbp:structure
|
four EF-hand motifs
|
|
gptkbp:UniProtID
|
P62158
|
|
gptkbp:bfsParent
|
gptkb:myosin_light-chain_kinase
gptkb:EF_hand_domain
gptkb:Myosin_Binding_Light_chain
gptkb:FKBP38
gptkb:Ras-like_protein_RIT2
gptkb:B_cell_receptor_signaling_pathway
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
calmodulin
|