Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
CaM
|
| gptkbp:binds |
calcium ions
|
| gptkbp:conservedIn |
yes
|
| gptkbp:discoveredIn |
1970
|
| gptkbp:domain |
EF-hand motif
|
| gptkbp:encodedBy |
CALM1 gene
CALM2 gene CALM3 gene |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
signal transduction
calcium binding |
| gptkbp:GO |
gptkb:GO:0005509
|
| https://www.w3.org/2000/01/rdf-schema#label |
calmodulin
|
| gptkbp:interactsWith |
gptkb:myosin_light-chain_kinase
gptkb:ryanodine_receptor gptkb:CaMKII adenylyl cyclase phosphodiesterase voltage-gated calcium channels calcineurin inositol trisphosphate receptor |
| gptkbp:length |
148
|
| gptkbp:locale |
gptkb:cell_membrane
gptkb:nucleus gptkb:cytoplasm |
| gptkbp:locatedOnChromosome |
human chromosome 14 (CALM1)
human chromosome 19 (CALM3) human chromosome 2 (CALM2) |
| gptkbp:molecularWeight |
16.7 kDa
|
| gptkbp:OMIM |
114180
|
| gptkbp:PDB |
1CLL
|
| gptkbp:postTranslationalModification |
phosphorylation
methylation acetylation |
| gptkbp:regulates |
gptkb:myosin_light-chain_kinase
ion channels protein kinases phosphatases phosphodiesterases Ca2+/calmodulin-dependent protein kinase II adenylyl cyclases |
| gptkbp:requires |
gptkb:synaptic_plasticity
cell cycle progression muscle contraction memory formation |
| gptkbp:significance |
mutations linked to cardiac arrhythmias
mutations linked to long QT syndrome mutations linked to sudden cardiac death |
| gptkbp:structure |
four EF-hand motifs
|
| gptkbp:UniProtID |
P62158
|
| gptkbp:bfsParent |
gptkb:myosin_light-chain_kinase
gptkb:TRPV1_receptor |
| gptkbp:bfsLayer |
6
|