|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
ion channel
|
|
gptkbp:activatedBy
|
gptkb:protons
gptkb:capsaicin
heat
|
|
gptkbp:alsoKnownAs
|
TRPV1
|
|
gptkbp:discoveredBy
|
gptkb:David_Julius
|
|
gptkbp:encodedBy
|
gptkb:TRPV1_gene
|
|
gptkbp:enemyOf
|
gptkb:capsaicin
gptkb:capsazepine
gptkb:resiniferatoxin
heat
acidic pH
|
|
gptkbp:expressedIn
|
gptkb:dorsal_root_ganglion
gptkb:trigeminal_ganglion
|
|
gptkbp:foundIn
|
sensory neurons
|
|
gptkbp:function
|
detects noxious heat
mediates pain sensation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
capsaicin receptor
|
|
gptkbp:inhibitedBy
|
gptkb:capsazepine
|
|
gptkbp:locatedOnChromosome
|
chromosome 17 (human)
|
|
gptkbp:memberOf
|
transient receptor potential channel family
|
|
gptkbp:modulatedBy
|
gptkb:endocannabinoids
prostaglandins
phosphorylation
lipids
|
|
gptkbp:permeableTo
|
calcium ions
sodium ions
|
|
gptkbp:relatedTo
|
inflammation
pain perception
thermal hyperalgesia
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:target
|
analgesic drugs
topical capsaicin creams
|
|
gptkbp:usedIn
|
drug development
pain research
|
|
gptkbp:bfsParent
|
gptkb:TRPV1_receptor
|
|
gptkbp:bfsLayer
|
6
|