protein kinase A

GPTKB entity

Statements (60)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activatedBy cyclic AMP
gptkbp:activity fluorescence-based assay
radioactive phosphate incorporation
gptkbp:alsoKnownAs gptkb:cAMP-dependent_protein_kinase
PKA
gptkbp:catalyzes PKA-C
gptkbp:composedOf catalytic subunits
regulatory subunits
gptkbp:discoveredBy gptkb:Earl_Sutherland
gptkbp:discoveredIn 1968
gptkbp:EC_number 2.7.11.11
gptkbp:foundIn eukaryotic cells
gptkbp:function phosphorylates serine and threonine residues
gptkbp:gene gptkb:PRKACA
gptkb:PRKACB
gptkb:PRKACG
gptkb:PRKAR1B
gptkb:PRKAR2A
gptkb:PRKAR2B
gptkb:PRKAR1A
https://www.w3.org/2000/01/rdf-schema#label protein kinase A
gptkbp:inhibitedBy protein kinase inhibitor peptide
gptkbp:involvedIn signal transduction
gene expression
cell growth
regulation of metabolism
gptkbp:molecularWeight approximately 40 kDa (catalytic subunit)
gptkbp:mutationAssociatedWith gptkb:Carney_complex
gptkb:Cushing's_syndrome
adrenal tumors
gptkbp:regulates lipid metabolism
transcription factors
cell cycle
glycogen metabolism
ion channel activity
gptkbp:relatedTo gptkb:protein_kinase_C
protein kinase G
gptkbp:structure tetramer (2 regulatory, 2 catalytic subunits)
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
mitochondria
gptkbp:subunit PKA-RI
PKA-RII
gptkbp:targetGene gptkb:Glycogen_synthase_kinase_3
gptkb:glycogen_synthase
gptkb:CREB
gptkb:AMPA_receptor
gptkb:Phosphodiesterase
gptkb:BAD_protein
gptkb:phospholamban
gptkb:troponin_I
DARPP-32
L-type calcium channel
Myosin light chain kinase
Tyrosine hydroxylase
glycogen phosphorylase kinase
gptkbp:bfsParent gptkb:cAMP_pathway
gptkb:TRPV1_receptor
gptkbp:bfsLayer 6