|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
cyclic AMP
|
|
gptkbp:activity
|
fluorescence-based assay
radioactive phosphate incorporation
|
|
gptkbp:alsoKnownAs
|
gptkb:cAMP-dependent_protein_kinase
PKA
|
|
gptkbp:catalyzes
|
PKA-C
|
|
gptkbp:composedOf
|
catalytic subunits
regulatory subunits
|
|
gptkbp:discoveredBy
|
gptkb:Earl_Sutherland
|
|
gptkbp:discoveredIn
|
1968
|
|
gptkbp:EC_number
|
2.7.11.11
|
|
gptkbp:foundIn
|
eukaryotic cells
|
|
gptkbp:function
|
phosphorylates serine and threonine residues
|
|
gptkbp:gene
|
gptkb:PRKACA
gptkb:PRKACB
gptkb:PRKACG
gptkb:PRKAR1B
gptkb:PRKAR2A
gptkb:PRKAR2B
gptkb:PRKAR1A
|
|
gptkbp:inhibitedBy
|
protein kinase inhibitor peptide
|
|
gptkbp:involvedIn
|
signal transduction
gene expression
cell growth
regulation of metabolism
|
|
gptkbp:molecularWeight
|
approximately 40 kDa (catalytic subunit)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Carney_complex
gptkb:Cushing's_syndrome
adrenal tumors
|
|
gptkbp:regulates
|
lipid metabolism
transcription factors
cell cycle
glycogen metabolism
ion channel activity
|
|
gptkbp:relatedTo
|
gptkb:protein_kinase_C
protein kinase G
|
|
gptkbp:structure
|
tetramer (2 regulatory, 2 catalytic subunits)
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:subunit
|
PKA-RI
PKA-RII
|
|
gptkbp:targetGene
|
gptkb:Glycogen_synthase_kinase_3
gptkb:glycogen_synthase
gptkb:CREB
gptkb:AMPA_receptor
gptkb:Phosphodiesterase
gptkb:BAD_protein
gptkb:phospholamban
gptkb:troponin_I
DARPP-32
L-type calcium channel
Myosin light chain kinase
Tyrosine hydroxylase
glycogen phosphorylase kinase
|
|
gptkbp:bfsParent
|
gptkb:cAMP_pathway
gptkb:glycogen_synthase
gptkb:CREB
gptkb:cAMP
gptkb:Glycogen_synthase
gptkb:ATF1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
protein kinase A
|