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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alternativeName
|
gptkb:mammalian_target_of_rapamycin
gptkb:mechanistic_target_of_rapamycin
gptkb:SEP
gptkb:SIK
gptkb:FRAP
RAFT1
RAPT1
FLJ44809
SFKB1
mTOR (in mammals)
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|
gptkbp:associatedWith
|
gptkb:tuberous_sclerosis
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
|
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gptkbp:component
|
gptkb:mTORC2_complex
mTORC1 complex
|
|
gptkbp:discoveredIn
|
gptkb:yeast
1991
|
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gptkbp:encodedBy
|
MTOR gene (in mammals)
|
|
gptkbp:enzyme
|
serine/threonine kinase
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:fullName
|
Target of Rapamycin protein
|
|
gptkbp:function
|
regulation of cell proliferation
regulation of cell survival
regulation of autophagy
regulation of cell growth
regulation of protein synthesis
|
|
gptkbp:homologInYeast
|
TOR1
TOR2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TOR protein
|
|
gptkbp:inhibitedBy
|
gptkb:rapamycin
|
|
gptkbp:locale
|
gptkb:lysosome
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~289 kDa (mTOR in humans)
|
|
gptkbp:orthologInC.elegans
|
let-363
|
|
gptkbp:orthologInDrosophila
|
dTOR
|
|
gptkbp:orthologInPlants
|
AtTOR (Arabidopsis thaliana)
|
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gptkbp:pathway
|
gptkb:PI3K/AKT/mTOR_pathway
|
|
gptkbp:phosphorylates
|
gptkb:4EBP1
gptkb:S6K1
gptkb:ULK1
gptkb:AKT
gptkb:TFEB
|
|
gptkbp:regulates
|
stress
growth factors
nutrient availability
oxygen levels
energy status
|
|
gptkbp:requires
|
embryonic development
metabolism
aging regulation
|
|
gptkbp:bfsParent
|
gptkb:TOR_Loop_3
|
|
gptkbp:bfsLayer
|
8
|