TNF alpha-induced protein 3

URI: https://gptkb.org/entity/TNF_alpha-induced_protein_3
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:A20
gptkbp:associatedWith autoimmune diseases
inflammatory diseases
gptkbp:domain zinc finger domain
OTU domain
gptkbp:encodedBy gptkb:TNFAIP3_gene
gptkbp:Entrez_Gene_ID 7128
ENSG00000118503
gptkbp:expressedIn endothelial cells
immune cells
epithelial cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function negative regulator of NF-kappaB signaling
ubiquitin-editing enzyme
https://www.w3.org/2000/01/rdf-schema#label TNF alpha-induced protein 3
gptkbp:inducedBy gptkb:tumor_necrosis_factor_alpha
gptkbp:interactsWith gptkb:TRAF6
gptkb:TRAF2
gptkb:NEMO
gptkb:RIPK1
gptkbp:involvedIn immune response
inflammatory response
gptkbp:length 790 amino acids
gptkbp:locale gptkb:cytoplasm
gptkbp:locatedOnChromosome 6q23.3
gptkbp:molecularWeight 87 kDa
gptkbp:mutationAssociatedWith gptkb:systemic_lupus_erythematosus
gptkb:Crohn's_disease
leukemia
psoriasis
rheumatoid arthritis
gptkbp:OMIM 191163
gptkbp:PDB 2VFJ
6J4V
gptkbp:regulates gptkb:TNF_signaling_pathway
gptkb:Toll-like_receptor_signaling_pathway
apoptosis
cell survival
inflammation
ubiquitination
cell death
inflammatory cytokine production
immune homeostasis
interleukin-1 signaling pathway
gptkbp:UniProtID P21580
gptkbp:bfsParent gptkb:TNFAIP3
gptkbp:bfsLayer 7