|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:A20
gptkb:TNF_alpha-induced_protein_3
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
psoriasis
rheumatoid arthritis
inflammatory bowel disease
|
|
gptkbp:biologicalProcess
|
ubiquitin ligase activity
deubiquitinase activity
|
|
gptkbp:discoveredBy
|
gptkb:Veronique_Beyaert
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodes
|
gptkb:A20_protein
|
|
gptkbp:Entrez_Gene_ID
|
7128
ENSG00000118503
|
|
gptkbp:expressedIn
|
immune cells
|
|
gptkbp:function
|
negative regulation of NF-kappaB signaling
ubiquitin-editing enzyme
|
|
gptkbp:HGNC_ID
|
HGNC:11830
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNFAIP3
|
|
gptkbp:interactsWith
|
gptkb:TRAF6
gptkb:CYLD
gptkb:IKK_complex
gptkb:TRAF2
gptkb:ABIN2
gptkb:ABIN3
gptkb:BCL10
gptkb:MALT1
gptkb:NEMO
gptkb:RIPK1
A20-binding inhibitor of NF-kappaB activation 1 (ABIN1)
|
|
gptkbp:length
|
790 amino acids
|
|
gptkbp:locatedOnChromosome
|
6q23.3
|
|
gptkbp:mutationAssociatedWith
|
inflammation
autoimmunity
|
|
gptkbp:OMIM
|
191163
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Tnfaip3
|
|
gptkbp:pathway
|
gptkb:TNF_signaling_pathway
gptkb:NF-kappaB_signaling_pathway
|
|
gptkbp:proteinFamily
|
zinc finger domain
OTU domain
|
|
gptkbp:regulates
|
gptkb:IL-1
gptkb:TNF-alpha
gptkb:LPS
apoptosis
inflammation
immune response
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P21580
|
|
gptkbp:bfsParent
|
gptkb:A20N
|
|
gptkbp:bfsLayer
|
6
|