|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:MAPK_pathway
gptkb:NF-κB_pathway
|
|
gptkbp:alternativeName
|
gptkb:CD282
|
|
gptkbp:associatedWith
|
tuberculosis
sepsis
autoimmune diseases
inflammatory diseases
|
|
gptkbp:discoveredBy
|
Shizuo Akira
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodedBy
|
gptkb:TLR2_gene
|
|
gptkbp:Entrez_Gene_ID
|
7097
|
|
gptkbp:expressedIn
|
dendritic cells
macrophages
monocytes
epithelial cells
neutrophils
|
|
gptkbp:formsHeterodimerWith
|
gptkb:TLR1
gptkb:TLR6
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
gptkb:Toll-like_receptor_2
|
|
gptkbp:function
|
innate immune response
pattern recognition receptor
GO:0002224 (toll-like receptor signaling pathway)
GO:0001530 (lipoprotein binding)
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
11848
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TLR2
|
|
gptkbp:interactsWith
|
gptkb:CD14
gptkb:TLR10
MyD88
TIRAP
|
|
gptkbp:length
|
784
|
|
gptkbp:locatedOnChromosome
|
human chromosome 4q31.3
|
|
gptkbp:location
|
gptkb:endosome
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
84 kDa
|
|
gptkbp:OMIM
|
603028
|
|
gptkbp:PDB
|
2Z7X
5D3I
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:recognizedBy
|
gptkb:lipoteichoic_acid
peptidoglycan
bacterial lipoproteins
|
|
gptkbp:speciesHomologs
|
mouse Tlr2
|
|
gptkbp:structure
|
TIR domain
leucine-rich repeat (LRR) domain
|
|
gptkbp:UniProtID
|
O60603
|
|
gptkbp:bfsParent
|
gptkb:Toll-like_receptors
|
|
gptkbp:bfsLayer
|
7
|