|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:HMG-1
gptkb:amphoterin
gptkb:sulfoglucuronyl_carbohydrate-binding_protein
|
|
gptkbp:discoveredBy
|
gptkb:M._Bustin
|
|
gptkbp:discoveredIn
|
1973
|
|
gptkbp:encodedBy
|
gptkb:HMGB1_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000189403
|
|
gptkbp:fullName
|
gptkb:High_Mobility_Group_Box_1
|
|
gptkbp:function
|
regulation of transcription
DNA binding
cytokine activity
chromatin remodeling
inflammatory mediator
|
|
gptkbp:gene
|
gptkb:HMGB1
|
|
gptkbp:GOID
|
GO:0003682
|
|
gptkbp:interactsWith
|
gptkb:TLR2
gptkb:TLR4
gptkb:RAGE
gptkb:p53
gptkb:NF-κB
|
|
gptkbp:length
|
215 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:13q12
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
extracellular space
|
|
gptkbp:molecularWeight
|
~25 kDa
|
|
gptkbp:OMIM
|
163905
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
2YRQ
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
methylation
acetylation
|
|
gptkbp:RefSeq
|
NM_002128
|
|
gptkbp:releaseMechanism
|
active secretion by immune cells
passive release from necrotic cells
|
|
gptkbp:role
|
gptkb:Alzheimer's_disease
gptkb:COVID-19
gptkb:cancer
gptkb:diabetes
gptkb:systemic_lupus_erythematosus
asthma
myocardial infarction
stroke
sepsis
rheumatoid arthritis
|
|
gptkbp:structure
|
contains two HMG-box domains
acidic C-terminal tail
|
|
gptkbp:UniProtID
|
gptkb:P09429
|
|
gptkbp:bfsParent
|
gptkb:HMG_box
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HMGB1
|